Depression - Herbal Relief for Depression

Herbal Relief for Depression

At least one out of every 20 Americans gets depressed each year, and many rely on anti-depressants to help them cope. A new study shows the herb St. John's Wort might be just as effective, and with fewer side effects.

The August 3, 1996 issue of the British Medical Journal contains an analysis of approximately 25 studies that suggest that St. John's Wort (Hypericum perforatum) is just as helpful as commonly used drugs, without side effects such as headaches or vomiting. Dr. Cynthia Mulrow, one of the study's authors, says the findings are not surprising. "Some of the commonly used medicines have a basis on herbs or have a basis in plants, and some of the ones were developed using plants."

Link to the Abstract on "St. John's Wort for Depression" from the
British Medical Journal, No. 7052, Volume 313, August 3, 1996

Although not well known in the United States until recently, researchers in Europe have been studying it for decades. Doctors in Germany have been prescribing it for depression and insurance companies have been paying for it. It has available in herb shops in Europe and the United States, but recently has been increasingly selling out as word has been getting around about it effectiveness. It comes in liquid, capsule and dried form.

Clinical Studies

Not long ago, experiments were done where mice infected with viruses similar to HIV were given St. John's Wort extract. The virus' progress was halted. This led to testing on human HIV and AIDS patients. The results are inconclusive, though anecdotal information reports a significant improvement in some patients.

St. John's Wort contains hypericin that inhibits monoamine oxidase, a bodily chemical associated with depression. It appears that hypericin does not act alone. Like many herbal medicines, St. John's Wort relies on the complex interplay of many constituents for its antidepressant actions. patients suffering from depression received relief, increased appetite, more interest in life, greater self-esteem and restoration of normal sleeping patterns.

St. John's Wort is available as tea, tincture, decoction, oil, and in capsule form. Teas should be made with 1-2 cups of flowers per 1 cup of boiling water. This tea can be drunk three times daily. The dosage of the tincture is 1/4 to 1 teaspoon up to three times daily.

perhaps most notable regarding St. John's Wort extract for depression has been favorable comparisons to standard prescription antidepressive drugs. These include maprotiline hydrochloride and imipramine.

In a multicenter trial, 135 patients with depression were given either St. John's Wort (900 mg/day) or imipramine (75 mg/day) for six weeks. Therapeutic success was determined using the HAMD, Clinical Global Impression (CGI), and Depression Scale according to Zerssen. HAMD score improved by 56% in the St. John's Wort group versus 45% for the imipramine group. Differences on the CGI and Zerssen scales were slightly better for St. John's Wort although not significantly different. Adverse reactions were reported in 16% of patients taking imipramine while only 12% of those taking St. John's Wort experienced side effects.


Dr. Donald Brown of Bastyr University recommends that persons with fair skin avoid exposure to strong sunlight and other sources of ultraviolet light when taking St. John's Wort because of some cases of photosensitivity that have been reported. He also advises avoiding foods that contain tyramine, alcoholic beverages, and medications such as tyrosine, narcotics, amphetamines, and over-the-counter cold and flu remedies while taking St. John's Wort. St. John's Wort should not be taken while also taking prescription antidepressants. It is also Dr. Brown's opinion that St. John's Wort should not be used during pregnancy or lactation.

According to Jonathan Zuess, MD (author of The Natural prozac program), tyramine seems to primarily be a problem if a person has high blood pressure. This is due to St. John's Wort working in a similar way to drugs that are monoamine oxidase inhibitors (MAOIs).

However, studies done in the 1990's have shown that the MAOI-like effect of St. John's Wort is negligible when it's used in normal doses. So it is unlikely that it would react with tyramine. In Germany, where doctors have had the most experience with St. John's Wort, it is considered safe to use in patients with high blood pressure.

Nonetheless, if you have high blood pressure, and your doctor agrees to your use of St. John's Wort, the following precautions should be taken:

  1. Have your blood pressure checked at least weekly for the first six weeks, and at least monthly thereafter.

  2. Do not eat foods containing tyramine.

Even if you do not have high blood pressure, do not take St. John's Wort with amino acid supplements (especially phenylalanine and tyrosine). Amino acids are a form of monoamines, which can pose a danger when mixed with St. John's Wort. The monoamines that you get in your diet (such as the amino acids in meat) are less concentrated and are not a hazard.


  1. Brown, N.D., Donald J., "St. John's Wort Overview" phytotherapy Review and Commentary (Seattle, Washington: Bastyr University's Department of Continuing Education, 1995)
  2. Castleman, Michael The Healing Herbs: The Ultimate Guide to the Curative power of Nature's Medicines (Emmaus, pennsylvania: Rodale press, 1991)
  3. Ernst E., "St. John's Wort, an anti-depressant A systematic, criteria-based review" phytomed 2: 6771, 1995
  4. Holmes, peter Energetics of Western Herbs, Integrating Western and Oriental Herbal Medicine Traditions, Vol. 2 (Boulder, Colorado: Artemis press, 1989)
  5. Holzl, J., Demisch L., and Gollnik B. "Investigations about antidepressive and mood changing effects of Hypericum perforatum" planta Med 55: 643, 1989
  6. Hutchens, Alma R. A Handbook of Native American Herbs (Boston, Massachussetts: Shambhala publishing, 1992)
  7. Reichert, R., "St. John's Wort for depression" Quart Rev Nat Med Spring, 1994, pp. 17-8
  8. Reichert, R., "St. John's Wort extract as a tricyclic medication substitute for mild to moderate depression" Quart Rev Nat Med Winter 1995, pp. 275-8
  9. Suzuki, O., et al, "Inhibition of monoamine oxidase by hypericin" planta Med 50: 272-4, 1984
  10. Vorbach, E. U., Hubner, W. D., and Arnoldt, K. H., "Effectiveness and tolerance of Hypericum extract li 160 in comparison with imipramine: Randomized double-blind study with 135 outpatients" J Geriatr psychiatry Neurol 7 (Suppl 1): S19-S23, 1994
  11. Weiner, ph.D., Michael, and Weiner, Janet Herbs That Heal: prescription for Herbal Healing (Mill Valley, California: Quantum Books, 1994)
  12. Willard, ph.D., Terry The Wild Rose Scientific Herbal (Calgary, Alberta: Wild Rose College of Natural Healing Ltd., 1991)

    These are the foods that contain tyramine or that contain bacteria with enzymes that can convert tyrosine to tyramine:

  • alcoholic beverages, wines, and beer
  • homemade yeast breads, products made with yeast
  • breads and crackers containing cheese
  • sour cream
  • aged game
  • liver, chicken liver
  • canned meats
  • commercial meat extracts
  • salami, sausage
  • aged cheese: blue, brick, Brie, Camembert, cheddar, Colby, Emmenthaler, Gouda, Mozzarella, parmesan, provolone, Romano, Roquefort
  • Salted dried fish; herring, cod, camlin; also pickled herring
  • Italian broad beans
  • eggplant
  • commercial gravies or meat extracts
  • soy sauce
  • any food that has been stored improperly or that is spoiled
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