Crohns Disease - Research


  • Crohn's research being done at the University of Central Florida in Orlando. (This is from a post-baccalaureate student working under Saleh A. Naser, Dept. of Molecular Biology and Microbiology and Ira Shafran, M.D. gastroenterology, Orlando.)

    "Generally speaking, the work we're doing know is an extension of (humoral) immune response work published by Dr. Saleh A. Naser (ph.D, Dept. of Microbiology and Molecular Biology, University of Central Florida), in 1994, which lent evidence to the association of M. paraTB to Crohn's disease. The current research is supported clinically by Ira Shafran, M.D. (Orlando, FL). We have shown a 92% positive rate for the presence of antigens specific to M. paraTB in the blood sera of 50+ patients confirmed to have CD. In contrast, our control sample of individuals presumed free of gastrintestinal disease showed a 27% positive rate, with no individual positive for more than one M. paraTB-specific antigen. Over 70% of CD patients tested positive for more than one antigen. We are continuing our study by testing sera of different types of control samples, amplifying M. paraTB DNA existing in CD patient tissue, and culturing M.paraTB cells from CD tissue.

    If any of your viewers are aware of avenues for research funding, we are in need of support."

  • Scientists in Sweden, the Netherlands, France and six other European countries are currently doing research on Crohn's and heredity. It has been found out that there are certain genetic changes in, among other chromosomes, chromosome 16 in Crohn's patients. A total of about 1,500 patients will be a part of this study, and I am one of them.
  • Around the world doctors have been researching about the possibilities of transplanting intestines on Crohn's patients. Right now it seems like the transplantations have worked in only half of the 240 cases.
  • Scientists all over the world have been trying to "turn off" the newly found "Crohn's-gene". As of today, no one has succeeded but (at least I hope) they will continue to find a way to turn it off.
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