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Common Cold - Vitamin C for preventing & Treating

Vitamin C for preventing & Treating

Douglas RM, Chalker EB, Treacy B
ABSTRACT

A substantive amendment to this systematic review was last made on 28 November 1997. Cochrane reviews are regularly checked and updated if necessary.

Background: The role of oral ascorbic acid (vitamin C) in the prevention and treatment of colds remains controversial despite many controlled trials. There have also been a number of efforts to synthesize and/or overview the results of these trials, and controversy over what these overviews tell us.

Objectives: The objective of this review was to answer the following two questions:
(1) Does regular high dosage supplementation with vitamin C reduce the incidence of colds
(2) Does taking vitamin C in high doses at the onset of a cold have a therapeutic effect

Search strategy: This review currently deals only with published trials from two previously published reviews by Kleijnen 1989 and Hemila 1992.

Selection criteria: Randomised and non-randomised trials of vitamin C taken to prevent or treat the common cold.

Data collection and analysis: Two reviewers independently extracted data and assessed trial quality.

Main results: Thirty trials were included. The quality of the included trials was variable. vitamin C in doses as high as one gram daily for several winter months, had no consistent beneficial effect on incidence of the common cold. For both preventive and therapeutic trials, there was a consistently beneficial but generally modest therapeutic effect on duration of cold symptoms. This effect was variable, ranging from -0.07% to a 39% reduction in symptom days. The weighted difference across all of the studies revealed a reduction of a little less than half a symptom day per cold episode, representing an 8% to 9% reduction in symptom days. There was no clear indication of the relative benefits of different regimes or vitamin C doses. However in trials that tested vitamin C after cold symptoms occurred, there was some evidence that a large dose produced greater benefits than lower doses.

Reviewers' conclusions: Long term daily supplementation with vitamin C in large doses daily does not appear to prevent colds. There appears to be a modest benefit in reducing duration of cold symptoms from ingestion of relatively high doses of vitamin C. The relation of dose to therapeutic benefit needs further exploration.

Citation: Douglas RM, Chalker EB, Treacy B. Vitamin C for preventing and treating the common cold (Cochrane Review). In: The Cochrane Library, Issue 1, 2000. Oxford: Update Software.

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