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Alzheimers Disease - Dementia, Vanadium trace mineral

Dementia, Vanadium trace mineral

The term "dementia" refers to a range of symptoms commonly found in people with brain diseases which result in the damage and loss of brain cells. Losing brain cells is a natural process, but with illnesses leading to dementia this occurs at a much faster rate and results in the person's brain not functioning in a normal manner.

The symptoms of dementia normally involve a gradual and slow deterioration of the person's ability to function, which never improves. The brain damage affects the person's mental functioning (memory, attention, concentration, language, thinking, etc.) and this in turn has repercussions on behaviour. But dementia is not just limited to the degenerative types of dementia. It refers to a syndrome which does not always follow the same course of development. In some cases the person's condition may improve or remain stable for some time. A small percentage of cases of dementia are treatable or potentially reversible, but in the vast majority of cases dementia leads to death. Most people die of "complications" such as pneumonia rather than of dementia itself. However, if it begins very late in life, the effects tend to be less severe. Although Alzheimer's disease is the most common form of dementia, there are a number of different kinds of dementia.

What is Alzheimer's Disease

Between 50 and 70 percent of all people with dementia are suffering from Alzheimer's disease - a degenerative disease, which slowly and progressively destroys brain cells. It is named after Alos Alzheimer, a German neurologist, who in 1907 first described the symptoms as well as the neuropathological features of Alzheimer's disease such as plaques and tangles in the brain. The disease affects memory and mental functioning (e.g. thinking and speaking, etc.), but can also lead to other problems such as confusion, changes of mood and disorientation in time and space.
At first the symptoms such as difficulty with memory and loss of intellectual abilities may be so slight that they go unnoticed, both by the person concerned and his or her family and friends. However, as the disease progresses, the symptoms become more and more noticeable and start to interfere with routine work and social activities. practical difficulties with daily tasks such as dressing, washing and going to the toilet gradually become so severe that in time the person becomes totally dependent on others. Alzheimer's disease is neither infectious nor contagious. It is a terminal illness, which causes a general deterioration in health. However, the most common cause of death is pneumonia, because as the disease progresses the immune system deteriorates and there is weight loss, which increases the risk of throat and lung infections.
In the past, the term Alzheimer's disease tended to be used to refer to a form of pre-senile dementia as opposed to senile dementia. However, there is now a greater understanding that the disease affects people both under and over 65 years of age. Consequently, the disease is now often referred to as pre-senile or senile dementia of the Alzheimer type depending on the age of the person concerned.

Who is likely to be affected

On the basis of comparisons of large groups of people with Alzheimer's disease with others who have not been affected, researchers suggest that there are a number of risk factors. This means that some people are more likely to suffer from the disease than others. However, it is unlikely that the disease could be traced to a single cause. It is more likely that a combination of factors lead to its development, with the importance of particular factors differing from one person to another.

Age

About one person out of twenty over the age of 65 suffers from Alzheimer's disease and less than one person in a thousand under the age of 65. However, it is important to note that although people do tend to become forgetful as times goes on, the vast majority of people over 80 stay mentally alert. This means that although the likelihood of suffering from Alzheimer's disease increases with age, old age does not itself cause the disease.

Nevertheless, recent evidence suggests that age related problems such as arteriosclerosis may be important contributing factors. Also, as people are now living longer than in the past, the number of people with Alzheimer's disease and other forms of dementia will most probably increase.

Sex

Some studies have suggested that more women are affected by the disease than men at any one time. However, this can be misleading because women as a group live longer than men. This means that if men were to live as long as women and did not die of other illnesses, the number suffering from Alzheimer's disease would be about the same as that for women.

Genetic factors/heredity

In an extremely limited number of families Alzheimer's disease is a dominant genetic disorder. Members of such families inherit from one of their parents the part of the DNA (the genetic make-up), which causes the disease. On average, half the children of an affected parent will develop the disease. For the members of such families who develop Alzheimer's disease, the age of onset tends to be relatively low, usually between 35 and 60. The onset is fairly constant within the family.

A link between chromosome 21 and Alzheimer's disease has been discovered. As Down's syndrome is caused by an anomaly in this chromosome, many children with Down's syndrome will develop Alzheimer's disease if they reach middle age, although they may not display the full range of symptoms.

Head injury

There is evidence to suggest that a person who has received a severe blow to the head may be at risk of developing Alzheimer's disease. This risk is higher if at the time of the injury the person is over 50, has a specific gene (apoE4) and lost consciousness just after the accident.

Other factors

There is no conclusive evidence to suggest that any particular group of people is more or less likely to develop Alzheimer's disease. Race, profession, geographical and socio-economic situation are not determinants of the disease. However, there is mounting evidence to suggest that people with a higher level of education are at less risk than those with a lower level of education.

Is Alzheimer's disease hereditary

Alzheimer's disease is not usually hereditary. It is therefore not caused by the genes received from a person's parents. Even if several members of a family have in the past been diagnosed as having Alzheimer's disease, this does not mean that another member of the family will necessarily develop it, as the majority of cases of Alzheimer's disease are not genetic. However, as the disease is so common in the elderly, it is not unusual for two or more family members over the age of 65 to have it.
Whether or not there are other members of a family with Alzheimer's disease, everyone risks developing the disease at some time. However, it is now known that there is a gene, which can affect this risk. This gene is found on chromosome 19 and it is responsible for the production of a protein called apolipoprotein E (ApoE). There are three main types of this protein, one of which (ApoE4), although uncommon, makes it more likely that Alzheimer's disease will occur. However, it does not cause the disease, but merely increases the likelihood. For example, a person of 50, would have a 2 in 1,000 chance of developing Alzheimer's disease instead of the usual 1 in 1,000, but might never actually develop it. Only half of people with Alzheimer's disease have ApoE4 and not everyone with ApoE4 suffers from it.

Is there a test that can predict Alzheimer's disease

It is inadvisable for people to waste their time or money on tests. There is no way to predict whether a particular person will develop the disease. It is possible to test for the ApoE4 gene, but such a test does not predict whether a particular person will develop Alzheimer's disease or not. It merely indicates that he or she is at greater risk. There are in fact people who have had the ApoE4 gene, lived well into old age and never developed Alzheimer's disease, just as there are people who did not have ApoE4, who did develop the disease. Therefore taking such a test carries the risk of unduly alarming or comforting somebody. Only in very rare families where Alzheimer's disease is a dominant genetic disorder unaffected relatives may take a predictive diagnostic test. The test must be preceded, accompanied and followed by comprehensive counselling.

How is Alzheimer's disease diagnosed

Alzheimer's disease is a form of dementia but is not necessarily caused by the same factors which cause other forms of dementia. However, despite a considerable amount of research, the actual cause of the disease remains unknown. There is no single test to determine whether someone has Alzheimer's disease. It is diagnosed by a process of elimination, as well as a careful examination of a person's physical and mental state, rather than by finding actual evidence of the disease.

physical and mental state

A carer or relative may be asked to provide information about the person's behaviour, e.g. difficulties getting dressed, washing, handling finances, keeping appointments, travelling alone, managing at work and using household appliances. A neuropsychological assessment is usually carried out. This involves finding out about possible problems with memory, language, planning and attention. A simple test called the Mini-Mental State Examination is often used. This involves the person being asked to answer questions such as: What is the date What city are we in What is this called (shown a watch). Another part of the test is to follow a series of simple instructions.

A number of tests may be carried out (e.g. blood and urine samples) in order to rule out the possibility of other illnesses which might explain the dementia syndrome or illnesses which might aggravate an already existing case of Alzheimer's disease. In addition to this, a few methods of brain imaging have been developed which produce images of the living brain, thereby revealing possible differences between the brains of people with Alzheimer's disease and those of non-affected individuals. These tests provide a risk-free and pain-free means of examining the brain of a living person. Although they cannot lead to a certain diagnosis of Alzheimer's disease, some doctors may use one or more of these techniques to give more weight to a diagnosis.

Methods of brain imaging

  • Magnetic Resonance Imaging
    This permits an extremely detailed image of the brain's structure. When one image is placed over another, taken a few months' later, it is possible to see changes at an early stage in a certain part of the brain.
  • CT (Computed Tomography) Scanning
    This measures the thickness of a part of the brain which becomes rapidly thinner in people with Alzheimer's disease.
  • SpECT (Single photon Emission Computed Tomography) Scanning
    This can be used to measure the flow of blood in the brain, which has been found to be reduced in people with Alzheimer's disease as a consequence of nerve cells not working properly.
  • pET (positron Emission Tomography)
    The use of this scanning technique is often limited to research settings. It can detect changes in the way the brain of someone with Alzheimer's disease functions. It can, for example, detect abnormal patterns of glucose usage by the brain.

What are the different kinds of diagnosis

There are three possibilities for a diagnosis of Alzheimer's disease : possible, probable and certain Alzheimer's disease.

possible Alzheimer's disease

A diagnosis of possible Alzheimer's disease is based on the observation of clinical symptoms and the deterioration of two or more cognitive functions (e.g. memory, language or thought) when a second illness is present which is not considered to be the cause of dementia, but makes the diagnosis of Alzheimer's disease less certain.

probable Alzheimer's disease

The diagnosis is classed as probable on the basis of the same criteria used to diagnose possible Alzheimer's disease, but in the absence of a second illness.

Certain Alzheimer's disease

Identification of characteristic plaques and tangles in the brain is the only way to confirm with certainty the diagnosis of Alzheimer's disease. For this reason, the third diagnosis, that of certain Alzheimer's disease, can only be made by brain biopsy or after an autopsy has been carried out.

Should the person be informed of their diagnosis

Nowadays more and more people with Alzheimer's disease are being informed of their diagnosis. This is perhaps due to a greater awareness of the disease. Some people might not want to be informed of the diagnosis. However, it is generally considered that everyone should have the right and be given the opportunity to decide whether they would rather know or waive this right. There are pros and cons involved in informing someone of their diagnosis. Also once the decision has been made to inform someone about their diagnosis the problem may arise of how to inform the person.

pros and cons of telling the person

In many cases a diagnosis is made as a result of concern expressed by members of the family. Often the person with dementia is unaware or does not agree that they have a problem. They are therefore not interested in obtaining a diagnosis. Some might feel depressed about knowing or feel that they would have been happier not knowing. However, there are many advantages to knowing. When a person knows that they have Alzheimer's disease and understands what it involves, they can plan how to make the most of the remaining years of relative unimpaired mental functioning. They can also take an active role in planning their care, arrange who will care for them, make important financial decisions and even decide to participate in research or make the necessary arrangements to donate brain tissue after their death for research.

How to inform the person of the diagnosis

Some relatives and friends may find it difficult to approach the subject. Some people would prefer to be told privately on a one-to-one basis, whereas others might find it more reassuring to be told in the presence of their family, who could give them moral and emotional support. Another possibility is to arrange for the person's doctor to tell them. It might help to arrange to go to the doctor together or for the person to go alone. The doctor could then answer any questions that either the carer and/or the person with dementia might have. The way the diagnosis is explained will depend on the person's ability to understand. Some people might understand an explanation of what the disease is, how it tends to progress and the consequences for daily living, whereas others might only be able to grasp that they have a disease which involves the loss of memory. Once informed, they may need support to come to terms with feelings of anger, self-blame, fear and depression. Some might be able to benefit from counselling and support groups, provided that the disease is not too far advanced.

Is there any treatment for Alzheimer's disease

As yet, there is no preventative or curative treatment for Alzheimer's disease. A number of drugs exist, which can help alleviate certain symptoms such as agitation, anxiety, depression, hallucinations, confusion and insomnia. Unfortunately, these drugs tend to be effective for a limited number of patients, only for a short period of time and may cause undesirable side effects. It is therefore generally considered advisable to avoid medication unless really necessary.
It has been found that patients suffering from Alzheimer's disease have reduced levels of acetylcholine - a neurotransmitter (chemical substance responsible for transmitting messages from one cell to another) which plays a role in memory processes. Certain drugs have been introduced in some countries, which can inhibit the enzyme responsible for destroying acetylcholine. In some patients these drugs improve memory and concentration. There is additional evidence that they have the potential to slow down the progression of symptoms temporarily. But, there is no evidence that they halt or reverse the process of cell damage. Such drugs treat the symptoms, but do not cure the disease. As European countries have widely differing legislation, we recommend that you consult a specialist in all cases.

The main characteristics of Alzheimer's disease

Memory loss

Loss of memory can have consequences on daily life in many ways, leading to communication problems, safety hazards and behavioural problems. In order to understand how memory is affected by dementia, it is useful to consider the different kinds of memory.

Episodic Memory

This is the memory people have of events in their life ranging from the most mundane to the most personally significant. Within episodic memory, there are memories classed as short term (having happened in the last hour) and those classed as long term (having occurred more than an hour ago). people with Alzheimer's disease, at the beginning of the illness, do not seem to have any difficulty remembering distant events but may, for example, forget having done something five minutes ago. Memories of distant events although not greatly affected tend to interfere with present activities. This can sometimes result in the person acting out routines from the past which are no longer relevant.

Semantic Memory

This category covers the memory of what words mean, e.g. a flower or a dog. Unlike episodic memory, it is not personal, but rather common to all those who speak the same language. It is the shared understanding of what a word means, which enables people to having meaningful conversations. As episodic and semantic memory are not located in the same place in the brain, one may be affected and the other not.

procedural Memory

    This is the memory of how to carry out actions both physically and mentally, for example, how to use a knife and fork or play chess. The loss of procedural memory can result in difficulties carrying out routine activities such as dressing, washing and cooking. This includes things which have become automatic. For this reason, some patients who have difficulty finding their words can still sing fairly well. Their procedural memory is still intact whereas their semantic memory (the meaning of words) has been damaged.

The Syndrome Apraxia/Aphasia/Agnosia

Apraxia

is the term used to describe the inability to carry out voluntary and purposeful movements despite the fact that muscular power, sensibility and coordination are intact. In everyday terms this might include the inability to tie shoelaces, turn a tap on, fasten buttons or switch on a radio.

Aphasia

is the term used to describe a difficulty or loss of the ability to speak or understand spoken, written or sign language as a result of damage to the corresponding nervous centre. This can become apparent in a number of ways. It might involve substituting a word which is linked by meaning (e.g. time instead of clock), using the wrong word but one which sounds similar (e.g. boat instead of coat) or use a completely different word with no apparent link. When accompanied by echolalia (the involuntary repetition of words or phrases spoken by another person) and the constant repetition of a word or phrase, the result can be a form of speech which is difficult for others to understand or a kind of jargon.

Agnosia

is the term used to describe the loss of the ability to recognise what objects are and what they are used for. For example, a person with agnosia might attempt to use a fork instead of a spoon, a shoe instead of a cup or a knife instead of a pencil etc. With regard to people, this might involve failing to recognise who people are, not due to memory loss but rather as a result of the brain not working out the identity of a person on the basis of the information supplied by the eyes.

Communication

people with Alzheimer's disease have difficulties both in the production and comprehension of language which in turn lead to other problems. Many patients also lose the ability to read and the ability to interpret signs.

personality change

people with Alzheimer's disease might behave totally out of character. A person who has always been quiet, polite and friendly might behave in an aggressive and ill-mannered way. Brusque and frequent mood changes are common.

Behaviour

A common symptom of Alzheimer's disease is wandering, both during the day and at night. There are a number of possible reasons for this wandering but due to communication problems, it is often impossible to find out what they are. Other symptoms affecting behaviour include incontinence, aggressive behaviour and disorientation in time and space

physical changes

Weight loss can occur even when the normal intake of food is maintained. It can also occur as a result of the person forgetting to chew or how to swallow, particularly in the later stages of the illness. Another consequence of Alzheimer's disease is the wasting away of muscle

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